เทคโนโลยี Orbitrap แบบไหนเหมาะกับงานของเราที่สุด ?
เป็นที่ยอมรับกันโดยกว้างขวางแล้วว่า เทคโนโลยี Orbitrap เป็นเทคโนโลยีของการวิเคราะห์มวลที่ดีที่สุดในปัจจุบัน การเลือกรุ่นของเครื่อง Orbitrap ก็เป็นสิ่งที่สำคัญไม่แพ้กัน ด้วยฟังก์ชั่นและฮาร์ดแวร์ในเครื่องรุ่นต่างกัน จึงเหมาะสมกับงานแต่ละงานมากน้อยต่างกัน
Choose a high-resolution, accurate-mass (HRAM) Orbitrap mass spectrometer that offers reliable screening performance with quantitative capability to take on more of your testing requirements that require confident, reportable results.
| Q Exactive Plus | Orbitrap Exploris 120 | |
|---|---|---|
| Ideal Applications | Forensic Toxicology, Clinical Research, Food & Environmental Safety Research, Basic Academic Research, Sport Anti-Doping, Biopharma development, Metabolomics, Lipidomics | Forensic Toxicology, Clinical Research, Food & Environmental Safety Testing, Basic Academic Research, Targeted/semi-targeted Metabolomics, Pharmaceuticals |
| Analyses | Unknown identification & confirmation, non-targeted and targeted screening and targeted quantitation | |
| Next-generation ion source interface | N/A | Yes |
| Quick start methods for various applications | N/A | Yes |
| Drag-n-drop method setup user interface | N/A | Yes |
| Almanac Web-Based Monitoring and Management | Requires Foundation 3.1 SP1 or later | |
| AcquireX Intelligent data acquisition | N/A | |
| Standard Features | ||
| Resolving Power @ m/z 200 | 140,000 (up to 280,000 with BioPharma option) | 120,000 |
| Mass Accuracy (Internal Calibration) | <1 ppm with internal calibration | <1 ppm for at least 5 days with EASY-IC ion source |
| Calibration procedures | Traditional Calmix | One-click calibration with FlexMix calibration solution |
| Mass Range | m/z 50 - 6,000 (up to 8000 with BioPharma option) | m/z 40 - 3,000 |
| Scan Speed | 12 Hz | 22 Hz |
| Dynamic Range | Up to 5 orders | |
| Ion Source interface | IonMax with H-ESI II probe | OptaMax NG ion source |
| Polarity Switching | 1 Hz | 1.4 Hz |
| Multiplexing | 10 | 20 |
| Scan Functions | Full-MS, AIF, SIM, PRM, (t-MS2 for Orbitrap Exploris 120), DIA | |
| Dissociation | In-source CID, HCD | |
| Optional Upgrades | ||
| Intact Protein Mode | Yes | N/A |
| Enhanced Resolution Mode | Yes | N/A |
| Sources | APCI/APPI Combination Ion Source EASY-Spray Sources Nanospray Flex Ion Sources | APCI/APPI Combination Ion Source EASY-Spray Sources Nanospray Flex Ion Sources |
Choose the high performance, high-resolution, accurate-mass (HRAM) Orbitrap mass spectrometer that's right for your translational research lab
| Orbitrap Exploris 240 | Orbitrap Exploris 480 | Q Exactive UHMR | ||
|---|---|---|---|---|
| Ideal Applications | Forensic Toxicology, Sport Anti-Doping, Food & Environmental Safety research and emerging contaminant testing, Extractables & Leachables, Academic Research, Biopharma development, Semi-targeted Metabolomics, Lipidomics, Clinical & Translational Research | Quantitative Proteomics, Protein Identification, Biopharma R&D, Clinical & Translational Research | Proteomics, Structural Biology, Protein Characterization | |
| Analyses | MS and MS/MS, Qual/Quan, Screening & Confirmation | MS and MS/MS, Screening & Confirmation | ||
| Advanced Data-Dependent Experiments | Precursor Fit | SureQuant, Precursor Fit, Boxcar Scanning | N/A | |
| Next-generation ion source interface | Yes | N/A | ||
| Quick start methods for various applications | Yes | N/A | ||
| Drag-and-drop method setup user interface | Yes | N/A | ||
| Almanac Web-Based Monitoring and Management | Requires Foundation 3.1 SP1 or later | |||
| AcquireX intelligent data acquisition | Yes | N/A | ||
| Standard Features | ||||
| Resolving Power @ m/z 200 | 240,000 | 480,000 | 200,000 at m/z 400 | |
| Mass Accuracy (Internal Calibration) | <1 ppm for up to 5 days with EASY-IC ion source | <1 ppm internal calibration | ||
| Calibration procedures | One-click calibration with FlexMix calibration solution | Traditional Calmix | ||
| EASY-IC Ion Source | <1 ppm for up to 5 days | N/A | ||
| Dynamic Range | Up to 5 orders | |||
| Mass Range | m/z 40 - 6000 (up to 8000 with BioPharma option) | m/z 40 - 6000 (up to 8000 with BioPharma option) | m/z 350 - 80,000 | |
| Scan Speed | Up to 22 Hz | Up to 40 Hz | Up to 12 Hz (at resolution setting of 12,500 @ m/z 400 | |
| Polarity Switching | 1.4 Hz | (1 full cycle <1 sec) | ||
| Ion Source | OptaMax NG ion source | IonMax with H-ESI II probe | ||
| Multiplexing | Up to 20 precursors/scan | N/A | ||
| Scan Functions | FS, AIF, SIM, t-MS2, DIA, ddHCD | FS, AIF, MS/MS, pseudo-MS3 | ||
| Dissociation | In-source CID, HCD | In-source trapping, HCD | ||
| Optional Upgrades | ||||
| Intact Protein Mode | Yes | |||
| High Mass Rangen(HMRn, up to 8000 m/z) | Yes | N/A | ||
| Sources | FAIMS Pro Duo interface APCI/APPI Combination Ion Source EASY-Spray Sources Nanospray Flex Ion Sources VeriSpray PaperSpray Ion Source | APCI/APPI Combination Ion Source EASY-Spray Sources Nanospray Flex Ion Sources | ||
Choose the maximum performance Tribrid Orbitrap mass spectrometer that's right for your discovery lab
| Orbitrap IQ-X Tribrid MS | Orbitrap Fusion Lumos Tribrid MS | Orbitrap Eclipse Tribrid MS | ||||||
|---|---|---|---|---|---|---|---|---|
| Ideal Applications | Small molecule characterization and elucidation research for applications such as Metabolomics, Drug development Met ID, Extactables and Leachables, Industrial Environmental Health and more | Multi-omics, TMT, Intact/top-down proteomics, Targeted Quantification, Protein-Protein Crosslinking | Multi-omics, TMT, Intact/top-down proteomics, Targeted Quantification, Protein-Protein Crosslinking, NativeOmics, LC-top-down mass spectrometry, Biotherapeutics | |||||
| Analyses | MS and MSn, Qualitative and Quantitative, Profiling, screening, and targeted consistently cap or uncap | |||||||
| Advanced Data-Dependent Experiments | Universal Method, Product Ion & Neutral Loss Triggered-MSn, Isolation offset, Intelligent MSn with Real-Time Library Search and Library builder | SPS MS3, Universal Method, Product Ion & Neutral Loss Triggered-MSn, Isolation offset, Quantitation/Confirmation Acquisition, SureQuant | Real-Time Search SPS MS3, Universal Method, Product Ion & Neutral Loss Triggered-MSn, Isolation offset, Quantitation/Confirmation Acquisition, SureQuant, Precursor Fit Filter | |||||
| AcquireX Acquisition Tool | Requires Thermo Scientific Orbitrap Tribrid Series 4.2 SP1QF1, 3.1 or greater | |||||||
| Almanac Web-Based Monitoring and Management | Requires Foundation 3.1 SP1 or later | |||||||
| Optional Upgrades | ||||||||
| EASY-ETD HD | No | Yes | ||||||
| UVPD Laser | Yes | Yes | ||||||
| High Mass Rangen (HMRn, up to 8,000 m/z) | No | Yes | ||||||
| Proton Transfer Charge Reduction (PTCR) | No | Yes | ||||||
| EASY-IC Ion Source | Yes | |||||||
| 1M Resolution | Yes | Yes | ||||||
| FAIMS Pro Duo Interface | Yes | |||||||